Hepatoid adenocarcinoma of the colon: a case report of a   rare aggressive cancer:

Antoinette  Bediako-Bowan; Charles  Ansah Larbi; Maurice Dordunoo; Veneranda Nyarko; Patrick Kafui Akakpo; Verna  Vanderpuye; Jonathan Dakubo

doi:10.46829/hsijournal.2024.12.6.2.1024-1029

Antoinette Bediako-Bowan Department of Surgery, University of Ghana Medical School, College of Health Science, University of Ghana, Accra, Ghana & Department of Surgery, Korle Bu Teaching Hospital, Accra, Ghana
Charles Ansah Larbi Department of Surgery, Korle Bu Teaching Hospital, Accra, Ghana & International Maritime Hospital, Tema, Ghana;
Maurice Dordunoo Pathology Without Boarders, Accra, Ghana
Veneranda Nyarko Pathology without Borders, Accra Ghana
Patrick Kafui Akakpo Pathology without Borders, Accra, Ghana & Department of Pathology, Cape Coast Teaching Hospital, Cape Coast, Ghana
Verna Vanderpuye National Radiotherapy Oncology and Nuclear Medicine Centre, Korle Bu Teaching Hospital, Accra, Ghana
Jonathan Dakubo Department of Surgery, University of Ghana Medical School, College of Health Science, University of Ghana, Accra, Ghana & Department of Surgery, Korle Bu Teaching Hospital, Accra, Ghana

DOI: https://doi.org/10.46829/hsijournal.2024.12.6.2.1024-1029

Keywords: Hepatoid adenocarcinoma, Pathological fracture, Radiotherapy, extended right hemicolectomy, palliative adjuvant therapy

Abstract

Hepatoid adenocarcinoma (HAC) is a rare and aggressive malignancy with histological and immunohistochemical features resembling hepatocellular carcinoma originating from non-hepatic organs. We report a case of HAC in a 34-year-old male, arising from the transverse colon, with metastases to the stomach, liver, lungs, and right femur. He presented with persistent anaemia and sub-acute intestinal obstructive
symptoms. Laparotomy confirmed a transverse colon tumour infiltrating the stomach, accompanied by hepatic and peritoneal lesions. He underwent extended right hemicolectomy and en-bloc resection of the distal stomach, with a histopathological diagnosis of hepatoid adenocarcinoma. Subsequently, he suffered a pathological hip fracture and was treated with open reduction and internal fixation, followed by
radiotherapy and palliative adjuvant chemotherapy. The disease progressed, leading to thoracic spine bone metastasis, necessitating further radiotherapy. He is alive, eight months post-surgery, despite a poor prognosis and disease progression

Hepatoid adenocarcinoma of the colon: a case report of a rare aggressive cancer

Hepatoid adenocarcinoma of the colon: a rare aggressive cancer

Abstract